Applying solitary-molecule optical and AFM imaging and power-spectroscopy methods, we seek to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our study pursuits incorporate:

Our group research bacterial cell division and is particularly aiming to represent a ‘bottom up biology’ in artificial cells which will autonomously divide. Our major curiosity lies in mobile division, chromatin framework, and spatial Management.

The subsequent articles are merged in Scholar. Their mixed citations are counted only for the initial report.

Nanofabrication of electrodes with sub-five nm spacing for transport experiments on solitary molecules and metal clusters

2015, discovery that condensin is usually a remarkably versatile protein structure; and initially detection of DNA knots making use of nanopores

Cornelis (Cees) Dekker (Haren, seven april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en fulfilled 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.

You are a Christian. If you could potentially make this type of synthetic mobile, would you be just one stage nearer to God, or would the part of God have diminished somewhat yet again?

2011, to start with in vitro measurements of transportation across just one biomimetic nuclear pore complicated; improvement of multiplexed magnetic tweezers for kilo-molecule experiments; and resolved the system of homology recognition in DNA homologous recombination

In 1993, as being a younger and keen affiliate professor at Delft University of Engineering, I'd in the beginning focused the analysis initiatives of my team on measuring the electrical conductance of only one conducting-polymer molecule. Inside two several years, we experienced created a device during which one wire of the phthalocyaninepolysiloxane polymer was related between two closely spaced metal nanoelectrodes.

Resolving the phase measurement in condensin-driven DNA loop extrusion identifies ATP binding since the stage-producing method

FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial mobile division

2001, discovery of one-electron transistors at home temperature based on nanotubes; realization of first logic circuits with carbon nanotube devices; and discovery from the molecular structure of DNA restore enzymes with AFM

Developments in nanotechnology within ceesdekker the 1990s produced developing electronic devices from single molecules a possibility. Cees Dekker recounts how his team produced a room-temperature transistor according to just one carbon nanotube.

Supercoiling-dependent DNA binding: quantitative modeling and apps to bulk and single-molecule experiments